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Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors

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Abstract

Experiments on animals with Lewis lung carcinoma and Ehrlich tumor showed that licorice (glycyrrhiza) extract and glyciram prepared from this plant improved the antitumor effect of cyclophosphamide. Glyciram reduced the toxic effect of the cytostatic on peripheral blood leukocytes. Licorice extract inhibited the growth of Ehrlich tumor and development of metastases in mice with Lewis lung carcinoma. Glyciram administered to mice after removal of Lewis lung carcinoma produced an antimetastatic effect and prevented relapses.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia

    E. D. Gol’dberg, E. N. Amosova, E. P. Zueva, T. G. Razina & S. G. Krylova

  2. V. L. Komarov Mountain Taiga Station, Far Eastern Division of Russian Academy of Sciences, Vladivostok, Russia

    P. S. Zorikov

Authors
  1. E. D. Gol’dberg
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  2. E. N. Amosova
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  3. E. P. Zueva
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  4. T. G. Razina
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  5. S. G. Krylova
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  6. P. S. Zorikov
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Corresponding author

Correspondence to E. P. Zueva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 213–217, February, 2008

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Gol’dberg, E.D., Amosova, E.N., Zueva, E.P. et al. Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors. Bull Exp Biol Med 145, 252–255 (2008). https://doi.org/10.1007/s10517-008-0063-0

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  • DOI: https://doi.org/10.1007/s10517-008-0063-0

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