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Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny

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Abstract

Experiments with selective agonists and antagonists of purinoceptors allowed us to evaluate the subtype of P2X receptors. We showed that the myocardium of 14–100-day-old rats contains functionally active P2X1 receptors. These receptors are involved in the realization of the positive inotropic effect of the atria and ventricles. Selective P2X1 receptor agonist β,γ-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular contractions. P2X1 receptor antagonist TNP-ATP abolished the effect of the agonist in rats of all age groups.

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Authors and Affiliations

  1. Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan, Russia

    A. A. Zverev, T. A. Anikina & F. G. Sitdicov

Authors
  1. A. A. Zverev
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  2. T. A. Anikina
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  3. F. G. Sitdicov
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Correspondence to A. A. Zverev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 133–135, February, 2008

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Zverev, A.A., Anikina, T.A. & Sitdicov, F.G. Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny. Bull Exp Biol Med 145, 174–176 (2008). https://doi.org/10.1007/s10517-008-0042-5

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  • DOI: https://doi.org/10.1007/s10517-008-0042-5

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