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Structural and mechanical characteristics of erythrocyte membranes in patients with type 2 diabetes mellitus

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The morphology and structure of erythrocyte cytoskeleton and local mechanical characteristics in patients with type 2 diabetes mellitus and donors were studied by atomic force microscopy. Poikilocytosis and anisocytosis, spatial reorganization of the cytoskeleton (loosening and condensation of the actin-spectrin network), and modification of local mechanical properties of erythrocytes were characteristic of diabetics. These results indicate significant heterogeneity of erythrocyte population in the patients, most likely due to the presence of erythrocytes of different age groups, which can promote the development of diabetes complications (angiopathy).

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Authors and Affiliations

  1. Gomel State Medical University, Gomel, Belarus

    M. N. Starodubtseva, T. G. Kuznetsova, N. I. Yegorenkov & S. N. Cherenkevich

Authors
  1. M. N. Starodubtseva
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  2. T. G. Kuznetsova
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  3. N. I. Yegorenkov
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  4. S. N. Cherenkevich
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Corresponding author

Correspondence to M. N. Starodubtseva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 106–110, January, 2008

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Starodubtseva, M.N., Kuznetsova, T.G., Yegorenkov, N.I. et al. Structural and mechanical characteristics of erythrocyte membranes in patients with type 2 diabetes mellitus. Bull Exp Biol Med 145, 99–103 (2008). https://doi.org/10.1007/s10517-008-0036-3

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  • DOI: https://doi.org/10.1007/s10517-008-0036-3

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