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Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist

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Abstract

Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2 cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. The concentration of serotonin in mesenteric lymph nodes was high during shock.

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Authors and Affiliations

  1. S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia

    G. I. Nezhinskaya, A. L. Vladykin & N. S. Sapronov

Authors
  1. G. I. Nezhinskaya
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  2. A. L. Vladykin
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  3. N. S. Sapronov
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Correspondence to G. I. Nezhinskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 61–63, January, 2008

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Nezhinskaya, G.I., Vladykin, A.L. & Sapronov, N.S. Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist. Bull Exp Biol Med 145, 55–57 (2008). https://doi.org/10.1007/s10517-008-0008-7

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  • DOI: https://doi.org/10.1007/s10517-008-0008-7

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