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Toxicology of nanoparticles

  • Nanotechnology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The paper considers the basic directions in fundamental and applied studies of the toxic effects of nanoparticles. Of particular importance is the study aimed at evaluation of the dependence of these effects on the shape, size, initial material, surface area, electric charge, and other physicochemical structural peculiarities, as well as on the dosage, mode of application, concentration in the target organ, and duration of action. The differences are stressed in the realization of general toxicity and genotoxicity of nanoparticles and chemical agents. The importance of the development of new methods of preclinical assessment of the safety of therapeutic nanoderivatives is emphasized.

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References

  1. N. O. Daugel-Dauge, A. D. Durnev, A. V. Kulakova, et al., Vestn. Ross. Akad. Med. Nauk, No. 1, 29–37 (1995).

  2. N. O. Daugel-Dauge, A. D. Durnev, and B. T. Velichkovskii, Toksikol. Vestn., No. 5, 11–13 (2001).

  3. A. D. Durnev, N. O. Daugel-Dauge, L. G. Korkina, et al., Byull. Eksp. Biol. Med., 115, No. 5, 484–486 (1993).

    CAS  Google Scholar 

  4. A. D. Durnev and S. B. Seredenin, Mutagens: Screening and Pharmacological Prevention [in Russian], Moscow (1998).

  5. A. D. Durnev, A. K. Zhanataev, E. A. Anisina, et al., Assessment of Genotoxic Properties of Natural and Synthetic Materials with Alkaline Gel Electrophoresis: Methodical Hints [in Russian], Moscow (2006).

  6. G. D. Zasukhina, Genetika, 41, No. 4, 520–535 (2005).

    PubMed  CAS  Google Scholar 

  7. A. B. Piotrovskii and O. I. Kiselev, Fullerenes in Biology [in Russian], St. Petersburg (2006).

  8. J. Curtis, M. Greenberg, J. Kester, et al., Toxicol. Rev., 25, No. 4, 245–260 (2006).

    Article  PubMed  CAS  Google Scholar 

  9. C. Medina, M. J. Santos-Martinez, A. Radomski, et al., Br. J. Pharmacol., 150, No. 5, 552–558 (2007).

    Article  PubMed  CAS  Google Scholar 

  10. S. K. Murthy, Int. J. Nanomedicine, 2, No. 2, 129–141 (2007).

    PubMed  CAS  Google Scholar 

  11. G. Oberdorster, E. Oberdorster, and J. Oberdorster, Environ. Health Perspect., 113, No. 7, 823–839 (2005).

    Article  PubMed  CAS  Google Scholar 

  12. L. Suter, L. E. Babiss, and E. B. Wheeldon, Chem. Biol., 11, No. 2, 161–171 (2004).

    Article  PubMed  CAS  Google Scholar 

  13. M. D. Waters and J. M. Fostel, Nat. Rev. Genet., 5, No. 12, 936–948 (2004).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. V. V. Zakusov State Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    A. D. Durnev

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  1. A. D. Durnev
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Correspondence to A. D. Durnev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 78–80, January, 2008

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Durnev, A.D. Toxicology of nanoparticles. Bull Exp Biol Med 145, 72–74 (2008). https://doi.org/10.1007/s10517-008-0005-x

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  • DOI: https://doi.org/10.1007/s10517-008-0005-x

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