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Mutant C57Bl/KsLeprdb/+ mice as a genetic model of type 2 diabetes mellitus

  • Genetics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The genetic model of diabetes mellitus was studied on mutant C57Bl/KsLeprdb/+ mice. These mice were characterized by high concentrations of glucose and glycosylated hemoglobin in the blood, polyuria, polyphagia, polydipsia, progressive obesity, biphasic morphological changes in insular islets of the pancreas (hyperplasia and atrophy), fatty degeneration of the liver, and hypoplasia of the spleen tissue and lymph nodes. Our results indicate that C57Bl/KsLeprdb/+ mice serve as an adequate model of type 2 diabetes mellitus. This model is suitable for testing of therapeutic methods for type 2 diabetes mellitus.

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References

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Authors and Affiliations

  1. Research Center of Biomedical Technologies, Russian Academy of Medical Sciences, Moscow

    O. I. Stepanova, N. N. Karkischenko, O. V. Baranova, T. V. Galahova, X. X. Semenov & T. B. Beskova

  2. Research Institute of Transplantology and Artificial Organs, Federal Agency for Health Care and Social Development, Moscow

    E. A. Stepanova, A. R. Zakir’yanov & N. A. Onischenko

Authors
  1. O. I. Stepanova
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  2. N. N. Karkischenko
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  3. O. V. Baranova
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  4. T. V. Galahova
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  5. X. X. Semenov
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  6. T. B. Beskova
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  7. E. A. Stepanova
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  8. A. R. Zakir’yanov
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  9. N. A. Onischenko
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Additional information

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 664–667, December, 2007

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Stepanova, O.I., Karkischenko, N.N., Baranova, O.V. et al. Mutant C57Bl/KsLeprdb/+ mice as a genetic model of type 2 diabetes mellitus. Bull Exp Biol Med 144, 813–816 (2007). https://doi.org/10.1007/s10517-007-0438-7

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  • DOI: https://doi.org/10.1007/s10517-007-0438-7

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