Skip to main content
SpringerLink
Log in

Mechanisms of mobilization of mesenchymal precursor cell under the effect of granulocytic colony-stimulating factor and hyaluronidase

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Binding of mesenchymal precursor cells to intact extracellular matrix and stroma increased under the effect of hyaluronidase and decreased after treatment of adhesion substrates with the enzyme. The stimulation of the release of progenitor elements into the blood by granulocytic CSF depended on the interaction of mesenchymal precursors with the feeder stimulating bone marrow microenvironment. Additional in vivo treatment with hyaluronidase potentiated mobilization of precursor cells by granulocytic CSF against the background of increased affinity of precursor to the stroma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. B. Vladimirskaya, Klin. Lab. Diagn., No. 4, 26–32 (2006).

  2. E. D. Goldberg, A. M. Dygai, and G. N. Zyuz’kov, Hypoxia and Blood System [in Russian], Tomsk (2006).

  3. E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, et al., Kletoch. Tekhnol. Biol. Med., No. 2, 115–119 (2007).

  4. E. D. Goldberg, A. M. Dygai, and V. P. Shakhov, Methods of Tissue Culture in Hematology [in Russian], Tomsk (1992).

  5. E. I. Deryugina, N. I. Drize, and I. L. Chertkov, Byull. Eksp. Biol. Med., 104, No. 7, 96–99 (1987).

    Google Scholar 

  6. Cytokine System. Theoretical and Clinical Aspects, Eds. V. A. Kozlov and S. V. Sennikov [in Russian], Novosibirsk (2004).

  7. T. Bonnefoix, P. Bonnefoix, M. Callanan, et al., J. Immunol., 167, No. 10, 5725–5730 (2001).

    PubMed  CAS  Google Scholar 

  8. P. S. in’t Anker, W. A. Noort, S. A. Scherjon, et al., Haematologica, 88, No. 8, 845–852 (2003).

    Google Scholar 

  9. T. Mosmann, J. Immunol. Methods, 65, Nos. 1–2, 55–63 (1983).

    Article  PubMed  CAS  Google Scholar 

  10. R. Stern, Glycobiology, 13, No. 12, 105R–115R (2003).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia

    E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov & V. V. Zhdanov

Authors
  1. E. D. Goldberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Dygai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. N. Zyuz’kov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. V. Zhdanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 12, pp. 652–656, December, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goldberg, E.D., Dygai, A.M., Zyuz’kov, G.N. et al. Mechanisms of mobilization of mesenchymal precursor cell under the effect of granulocytic colony-stimulating factor and hyaluronidase. Bull Exp Biol Med 144, 802–805 (2007). https://doi.org/10.1007/s10517-007-0435-x

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0435-x

Key Words

Search

Navigation