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Carcinogenic effect of an antitumor drug etoposide in laboratory animals

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Abstract

Intravenous injection of antitumor drug etoposide in the maximum tolerated dose was followed by the development of breast cancer in 38.1% female Wistar rats and 6.7% female outbred mice.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia

    T. I. Fomina, T. G. Borovskaja & E. A. Timina

  2. Department of Pathoanatomy, Siberian State Medical University, Federal Agency for Health Care and Social Development, Russia

    V. M. Perelmuter, S. V. Vtorushin & M. V. Zavjalova

Authors
  1. T. I. Fomina
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  2. V. M. Perelmuter
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  3. S. V. Vtorushin
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  4. M. V. Zavjalova
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  5. T. G. Borovskaja
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  6. E. A. Timina
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Corresponding author

Correspondence to T. I. Fomina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 568–571, November, 2007

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Fomina, T.I., Perelmuter, V.M., Vtorushin, S.V. et al. Carcinogenic effect of an antitumor drug etoposide in laboratory animals. Bull Exp Biol Med 144, 725–727 (2007). https://doi.org/10.1007/s10517-007-0416-0

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  • DOI: https://doi.org/10.1007/s10517-007-0416-0

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