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FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice

  • Oncology
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Abstract

o-Aminoazotoluene was more potent than 3′-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3′-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    L. O. Bryzgalov, N. I. Ershov & S. I. Ilnitskaya

Authors
  1. L. O. Bryzgalov
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  2. N. I. Ershov
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  3. S. I. Ilnitskaya
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Correspondence to L. O. Bryzgalov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 565–567, November, 2007

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Bryzgalov, L.O., Ershov, N.I. & Ilnitskaya, S.I. FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice. Bull Exp Biol Med 144, 722–724 (2007). https://doi.org/10.1007/s10517-007-0415-1

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  • DOI: https://doi.org/10.1007/s10517-007-0415-1

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