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Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of γ-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generation of reactive oxygen species by neutrophils from patients with this syndrome was higher than in healthy donors. Our results indicate that glutathione S-transferase genes are involved in the resistance to mutagenic agents and demonstrate medical and genetic peculiarities of patients with Ehlers-Danlos syndrome.

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References

  1. Yu. A. Vladimirov and M. P. Sherstnev, Itogi Nauki Tekhniki. Ser. Biofiz., 24, 41–44 (1989).

    Google Scholar 

  2. A. D. Durnev and S. B. Seredenin, Mutagens. Screening and Pharmacological Prevention of Influences [in Russian], Moscow (1998).

  3. N. S. Kuz’mina, I. M. Vasil’eva, G. D. Zasukhina, et al., Radiats. Biol. Radioekol., 46, No. 4, 424–427 (2006).

    CAS  Google Scholar 

  4. S. Angelini, R. Kumar, F. Carbone, et al., Mutat. Res., 570, No. 1, 105–117 (2005).

    PubMed  CAS  Google Scholar 

  5. M. Gajecka, M. Rydzanicz, R. Jaskula-Sztul, et al., Ibid., 574, Nos. 1–2, 112–123 (2005).

    PubMed  CAS  Google Scholar 

  6. F. J. Gonzales, Ibid., 569, Nos. 1–2, 101–110 (2005).

    Google Scholar 

  7. B. Karahalil, S. Sardas, N. A. Kocabas, et al., Ibid., 515, Nos. 1–2, 135–140 (2002).

    PubMed  CAS  Google Scholar 

  8. T. Nicotera, K. Thusu, and P. Dandona, Cancer Res., 53, No. 21, 5104–5107 (1993).

    PubMed  CAS  Google Scholar 

  9. I. Persson, I. Johansson, H. Bergling, et al., FEBS Lett., 319, No. 3, 207–211 (1993).

    Article  PubMed  CAS  Google Scholar 

  10. V. Steenkamp, H. Grimmer, M. Semano, and M. Gulumian, Mutat. Res., 581, Nos. 1–2, 35–42 (2005).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Russia

    N. S. Kuz’mina, I. M. Vasil’eva & G. D. Zasukhina

  2. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia

    E. V. Shipaeva

  3. Moscow Institute of Pediatrics and Child Surgery, Russian Ministry of Health, Russia

    A. N. Semyachkina, L. P. Kovalenko & A. D. Durnev

Authors
  1. N. S. Kuz’mina
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  2. E. V. Shipaeva
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  3. A. N. Semyachkina
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  4. I. M. Vasil’eva
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  5. L. P. Kovalenko
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  6. A. D. Durnev
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  7. G. D. Zasukhina
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 560–564, November, 2007

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Kuz’mina, N.S., Shipaeva, E.V., Semyachkina, A.N. et al. Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome. Bull Exp Biol Med 144, 717–721 (2007). https://doi.org/10.1007/s10517-007-0414-2

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  • DOI: https://doi.org/10.1007/s10517-007-0414-2

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