Abstract
A large sample of Wistar rats was divided into 2 groups of high-anxiety and low-anxiety animals by the time spent in the open arms of the elevated plus-maze. This selection was based on the criterion of time (low-anxiety animals, not less than 10 sec; high-anxiety animals, not more than 2 sec). Immunization with T-dependent antigen was performed on the day of behavioral testing. The number of rosette-forming cells in high-anxiety rats significantly decreased on day 5 after immunization. A genetically determined relationship probably exists between low activity of the immune response and high level of reactive anxiety.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. F. Avgustinovich, O. V. Alekseenko, I. V. Bakshtanovskaya, et al., Uspekhi Fiziol. Nauk, 35, No. 4, 19–40 (2004).
E. L. Al’perina and T. A. Pavina, Byull. Eksp. Biol. Med., 135, No. 11, 541–543 (1999).
E. B. Arushanyan and E. V. Beier, Uspekhi Fiziol. Nauk, 35, No. 4, 49–64 (2004).
L. V. Devoino, E. L. Al’perina, N. N. Kudryavtseva, and N. K. Popova, Ros. Fiziol. Zh., 77, No. 12, 62–67 (1991).
G. V. Idova, T. A. Pavina, E. L. Al’perina, and L. V. Devoino, Immunologiya, No. 1, 24–26 (2000).
O. L. Kolesnikov, I. I. Dolgushin, and G. A. Selyanina, Byull. Eksp. Biol. Med., 142, No. 8, 185–187 (2006).
S. V. Magaeva and S. G. Morozov, Neuroimmunophysiology [in Russian], Moscow (2005).
C. Belzung and G. Le Pape, Physiol. Behav., 56, No. 3, 623–628 (1995).
K. B. Koh and Y. Lee, Psychother. Psychosom., 73, No. 5, 286–292 (2004).
B. Leonard and G. Song, Pharmacol. Biochem. Behav., 54, No. 1, 299–303 (1996).
J. E. Park, S. W. Kim, Q. Park, et al., J. Korean Med. Sci., 20, No. 2, 215–219 (2005).
R. J. Rodgers and A. Dalvi, Neurosci. Biobehav. Rev., 21, No. 6, 801–810 (1997).
A. B. Segal, S. Bruno, and W. C. Forte, Allergol. Immunopathol. (Madr.), 34, No. 4, 136–140 (2006).
S. C. Segerstrom, M. E. Kemeny, and M. L. Laudenslager, Psychoneuroimmunology, Ed. R. Ader, New York (2001), Vol. 2, pp. 87–109.
D. M. Silberman, V. Ayelli-Edgar, M. Zorrilla-Zubilete, et al., Brain Behav. Immun., 18, No. 1, 81–90 (2004).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 549–551, November, 2007
Rights and permissions
About this article
Cite this article
Loskutova, L.V., Idova, G.V. & Gevorgyan, M.M. Immune response in Wistar rats with high and low level of situational anxiety. Bull Exp Biol Med 144, 706–708 (2007). https://doi.org/10.1007/s10517-007-0411-5
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0411-5