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N-methyl-D-aspartate receptors and amnesia in mice with depression-like state

  • Physiology
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Abstract

We studied the effect of activation (N-methyl-D-aspartic acid and D-cycloserine) and blockade (dizocilpine and 7-chlorokynurenic acid) of N-methyl-D-aspartate receptors on the development of amnesia in intact and depressive mice under conditions of conditioned passive avoidance response. Agonists and antagonists of N-methyl-D-aspartate receptors produce a strong antiamnesic effect in mice with behavioral despair. In intact animals, only N-methyl-D-aspartic acid and D-cycloserine improved passive avoidance performance.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    N. I. Dubrovina, D. R. Zinovyev & D. V. Zinovyeva

Authors
  1. N. I. Dubrovina
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  2. D. R. Zinovyev
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  3. D. V. Zinovyeva
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Correspondence to N. I. Dubrovina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 484–486, November, 2007

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Dubrovina, N.I., Zinovyev, D.R. & Zinovyeva, D.V. N-methyl-D-aspartate receptors and amnesia in mice with depression-like state. Bull Exp Biol Med 144, 647–649 (2007). https://doi.org/10.1007/s10517-007-0394-2

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  • DOI: https://doi.org/10.1007/s10517-007-0394-2

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