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Bulletin of Experimental Biology and Medicine

, Volume 144, Issue 4, pp 520–522 | Cite as

Oxidative destruction of mitochondrial translation products after fractionated irradiation of rats with tumor

  • M. M. Marchenko
  • G. P. Kopyl’chuk
  • O. M. VoloshchukEmail author
Article

Abstract

We demonstrated specific features of oxidative damage to mitochondrial translation products in animals were revealed after fractionated X-ray exposure in low doses. Differences were found in carbonylation and oxidation of SH groups in irradiated rats and irradiated tumor-bearing animals. Our results indicate that preliminary fractionated X-ray exposure determines oxidative damage to these mitochondrial proteins only at the initial stage of the study, while in the follow-up period major role is played the by tumor development.

Key Words

mitochondrial translation products oxidative modification Guerin carcinoma 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. M. Marchenko
    • 1
  • G. P. Kopyl’chuk
    • 1
  • O. M. Voloshchuk
    • 1
    Email author
  1. 1.Department of BiochemistryYurii Fed’kovich Chernovitsk National UniversityRussia

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