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Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes

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Abstract

The level of natural apoptosis in rat thymus on day 18 of embryo development attained 25%, while at subsequent terms it was about 5%. In the spleen, this parameter gradually decreased from 15 to 37% starting from day 18 of embryo development to postnatal day 30. Tactivin prevented the development of dexamethasone-induced apoptosis in thymocytes of 30-day-old rats, but had no effect on spontaneous apoptosis. Tactivin can be used as a modulator of apoptotic processes.

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Authors and Affiliations

  1. N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Science, Moscow

    V. Ya. Arion, V. I. Mel’nikova, M. A. Afanas’eva, S. N. Moskvina & L. A. Zakharova

  2. Institute of Physicochemical Medicine, Federal Agency on Health Care and Social Development, Moscow

    V. Ya. Arion, V. I. Mel’nikova, M. A. Afanas’eva, S. N. Moskvina & L. A. Zakharova

Authors
  1. V. Ya. Arion
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  2. V. I. Mel’nikova
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  3. M. A. Afanas’eva
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  4. S. N. Moskvina
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  5. L. A. Zakharova
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Corresponding author

Correspondence to S. N. Moskvina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Supplement 2, pp. 109–111, April, 2007

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Arion, V.Y., Mel’nikova, V.I., Afanas’eva, M.A. et al. Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes. Bull Exp Biol Med 144, 479–481 (2007). https://doi.org/10.1007/s10517-007-0355-9

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  • DOI: https://doi.org/10.1007/s10517-007-0355-9

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