Abstract
Selective increase of DNA-binding activity of constitutive androstane receptor was detected in rat and mouse liver in response to aminoazo dyes exhibiting hepatocarcinogenic activity for these species (ortho-aminoazotoluene for mice and 3′-methyl-4-dimethylaminobenzene for rats). Competition of azo dyes with 3H-5α-androst-16-ene-3α-ol (a well-known ligand of constitutive androstane receptor) for binding to liver cell cytosol proteins was studied. Ortho-aminoazotoluene and 3′-methyl-4-dimethylaminobenzene were better competitors for cytosol proteins from mouse and rat liver, respectively.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 316–319, September, 2007
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Pakharukova, M.Y., Smetanina, M.A., Kaledin, V.I. et al. Activation of constitutive androstane receptor under the effect of hepatocarcinogenic aminoazo dyes in mouse and rat liver. Bull Exp Biol Med 144, 338–341 (2007). https://doi.org/10.1007/s10517-007-0327-0
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DOI: https://doi.org/10.1007/s10517-007-0327-0