Abstract
In experiments on rats, uridine-5′-monophosphate and uridine-5′-triphosphate reduced the intensity of anaerobic glycolysis and preserved glycogen stores and creatine phosphate balance during the first 60 min after occlusion of the left coronary artery. However, the energy-protective effect of uridine-5′-triphosphate developed 15 min later than the effect of uridine-5′-monophosphate. Uridine-5′-monophosphate, but not uridine-5′-triphosphate, reduced T wave amplitude on ECG and decreased the volume of ischemic injury to the myocardium.
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References
A. E. Aleksandrova, Eksp. Klin. Farmakol., 68, No. 1, 72–78 (2005).
V. V. Bul’on, L. K. Khnychenko, N. S. Sapronov, et al., Ibid. 65, No. 1, 27–29 (2002).
P. A. Galenko-Yaroshevskii and V. V. Gatsura, Experimental Aspects of Optimization of Drug Therapy for Acute Myocardial Ischemia [in Russian], Moscow (2001).
V. V. Yeliseev, O. M. Rodionova, and N. S. Sapronov, Vestn. Aritmol., No. 20, 66–69 (2000).
V. V. Yeliseev, O. M. Rodionova, N. S. Sapronov, and N. O. Selizarova, Pat. Fiziol., No. 2, 13–15 (2002).
I. V. Zarubina and P. D. Shabanov, Med. Akad. Zh., No. 2, 49–57 (2003).
N. S. Sapronov, V. V. Bul’on, I. B. Krylova, et al., Byull. Eksp. Biol. Med., 141, No. 1, 49–52 (2006).
N. V. Solenkova, L. N. Maslov, and J. M. Downey, Pat. Fiziol., No. 2, 28–31 (2006).
H. Adrehali, Acta Biochim. Pol., 51, No. 2, 379–390 (2004).
G. P. Connolly and J. A. Duley, Trends Pharmacol. Sci., 20, No. 5, 218–225 (1999).
W. M. Frederiks, J. P. Shellens, F. Marx, et al., Basic Res. Cardiol., 88, No. 2, 130–140 (1993).
I. B. Krylova, E. V. Kachaeva, O. M. Rodionova, et al., Exp. Gerontol., 41, No. 7, 697–703 (2006).
S. P. Kunapuli and J. L. Daniel, Biochem. J., 336, Pt. 3, 513–523 (1998).
B. O’Rourke, Clin. Res., 94, No. 4, 420–432 (2004).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 297–300, September, 2007
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Bul’on, V.V., Krylova, I.B., Rodionova, O.M. et al. Comparative study of cardioprotective effects of uridine-5′-monophosphate and uridine-5′-triphosphate during the early periods of acute myocardial ischemia. Bull Exp Biol Med 144, 322–325 (2007). https://doi.org/10.1007/s10517-007-0323-4
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DOI: https://doi.org/10.1007/s10517-007-0323-4