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Clofibrate and dalargin increase luminol-dependent chemiluminescence of mouse blood

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Abstract

The effects of hypolipidemic drug clofibrate and polypeptide dalargin on activity of the neutrophil peroxidase system in mice were studied using the method of luminol-enhanced chemiluminescence. Clofibrate and dalargin increased the chemiluminescence of mouse whole blood. Their combined use several-fold potentiated this effect. It is expected that combined use of hypolipidemics and polypeptides will open a new trend in the search for stimulators of oxygen-dependent nonspecific immunity.

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Authors and Affiliations

  1. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    V. M. Mushtakova & V. V. Rogovin

Authors
  1. V. M. Mushtakova
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  2. V. V. Rogovin
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Correspondence to V. M. Mushtakova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 291–292, September, 2007

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Mushtakova, V.M., Rogovin, V.V. Clofibrate and dalargin increase luminol-dependent chemiluminescence of mouse blood. Bull Exp Biol Med 144, 317–318 (2007). https://doi.org/10.1007/s10517-007-0321-6

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  • DOI: https://doi.org/10.1007/s10517-007-0321-6

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