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Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats

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Abstract

3H-thymidine autoradiography and chemiluminescence study demonstrated pronounced effect of dalargin on the state of the gastric mucosa in albino rats. Dalargin stimulated DNA synthesis in the epithelium of the gastric mucosa and increased buffer capacity of its antiradical and antioxidant systems. Dalargin analogue not containing arginine ([D-Ala2]-leu-enkephalin) had little effect on these parameters. NO synthase inhibitor L-NAME abolished the effects of dalargin on DNA synthesis in the gastric mucosa. Our results suggest that the NO system plays an important role in the effect of dalargin on the gastric mucosa.

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Authors and Affiliations

  1. Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk

    E. U. Zivotova, M. U. Fleishman, E. N. Sazonova & S. S. Timoshin

  2. Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Russia

    O. A. Lebedko

Authors
  1. E. U. Zivotova
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  2. M. U. Fleishman
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  3. O. A. Lebedko
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  4. E. N. Sazonova
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  5. S. S. Timoshin
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Correspondence to S. S. Timoshin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 288–290, September, 2007

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Zivotova, E.U., Fleishman, M.U., Lebedko, O.A. et al. Effect of dalargin on DNA synthesis in the gastric mucosa of albino rats. Bull Exp Biol Med 144, 314–316 (2007). https://doi.org/10.1007/s10517-007-0320-7

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  • DOI: https://doi.org/10.1007/s10517-007-0320-7

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