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Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB

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Abstract

The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression.

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Authors and Affiliations

  1. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russia

    A. N. Saprin, Ya. N. Kotova, Yu. A. Gavrilova, N. S. Chermnykh & N. P. Shcherbak

  2. Institute of Cytochemistry and Molecular Pharmacology, Russia

    E. V. Kalinina

  3. Russian People’s Friendship University, Moscow

    N. N. Chernov

Authors
  1. E. V. Kalinina
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  2. N. N. Chernov
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  3. A. N. Saprin
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  4. Ya. N. Kotova
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  5. Yu. A. Gavrilova
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  6. N. S. Chermnykh
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  7. N. P. Shcherbak
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Corresponding author

Correspondence to E. V. Kalinina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 274–276, September, 2007

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Kalinina, E.V., Chernov, N.N., Saprin, A.N. et al. Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB. Bull Exp Biol Med 144, 301–303 (2007). https://doi.org/10.1007/s10517-007-0316-3

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  • DOI: https://doi.org/10.1007/s10517-007-0316-3

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