Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents

Abstract

Contractile activity of atrial and ventricular myocardial strips isolated from rats of various age was examined under conditions of blockade of non-selective hyperpolarization-activated cation currents. Addition of ZD7288, a blocker of non-selective hyperpolarization-activated cation currents, to the perfusion solution increased the contraction force of atrial and ventricular strips in 1-, 8-, and 20-week rats, but produced an opposite effect on contractile activity of atrial and ventricular strips in 3-week rats.

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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 244–246, September, 2007

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Zefirov, T.L., Gibina, A.E., Sergejeva, A.M. et al. Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents. Bull Exp Biol Med 144, 273–275 (2007). https://doi.org/10.1007/s10517-007-0308-3

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Key Words

  • heart
  • inotropy
  • hyperpolarization-activated currents
  • ontogeny
  • rat