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Comparative study of the effects of trophoblastin and polydeoxyribonucleotide preparations on cultured skin fibroblast

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied the effects of trophoblastin and polydeoxyribonucleotide on the morphology and functional characteristics of fibroblasts in the culture of skin cells. Positive effects of trophoblastin and polydeoxyribonucleotide on fibroblast growth and survival during culturing were demonstrated. Trophoblastin exhibited similar effects on cells of early and late passages. Polydeoxyribonucleotide exhibited a more pronounced effect on cells of late passages, whose growth activity decreased with age. Being a multicomponent preparation, trophoblastin stimulated processes leading to positive dynamic of cell development and vital activity. Polydeoxyribonucleotide had a favorable impact on functioning of basal cell structures at the level of cell nucleus and maintained high level of cells with complete DNA set.

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Authors and Affiliations

  1. Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency for High-Technology Medical Care, Moscow

    O. G. Pleshkanyova, I. V. Dubrovina, Zh. I. Teryushkova & G. T. Sukhikh

Authors
  1. O. G. Pleshkanyova
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  2. I. V. Dubrovina
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  3. Zh. I. Teryushkova
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  4. G. T. Sukhikh
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Corresponding author

Correspondence to O. G. Pleshkanyova.

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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 173–177, July, 2007

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Pleshkanyova, O.G., Dubrovina, I.V., Teryushkova, Z.I. et al. Comparative study of the effects of trophoblastin and polydeoxyribonucleotide preparations on cultured skin fibroblast. Bull Exp Biol Med 144, 154–158 (2007). https://doi.org/10.1007/s10517-007-0277-6

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  • DOI: https://doi.org/10.1007/s10517-007-0277-6

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