Abstract
Colony-forming activity of bone marrow cells in 3-and 12-month-old Wistar rats does not differ by the number of early and erythroid precursors and by the formation of granulocyte-macrophage colonies. In senescence-accelerated OXYS rats, the number of early and erythroid precursors significantly increases by the age of 12 months and surpasses the corresponding values in Wistar rats. The number of granulocyte-macrophage colonies in OXYS rats does not change with age, but the numbers of these colonies formed at the age of 3 and 12 months in these animals are higher than in Wistar rats. As a result, the total number of hemopoietic colonies in 12-month-old OXYS rats 2-fold surpassed that in 12-month-old Wistar rats. Activation of granulopoiesis and increased numbers of early and erythroid precursors indicate deep changes in the functional status of the hemopoietic stem cell in 1-year-old OXYS rats in the direction characteristic of aging animals.
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References
V. N. Anisimov, Molecular and Physiological Mechanisms of Aging [in Russian], St. Petersburg (2003).
N. G. Kolosova, P. A. Lebedev, A. Zh. Fursova, et al., Usp. Gerontol., No. 12, 143–148 (2003).
E. B. Markova, L. A. Obukhova, and N. G. Kolosova, Byull. Eksp. Biol. Med., 136, No. 10, 427–429 (2003).
O. V. Falameyeva, M. A. Sadovoi, Yu. V. Khrapova, and N. G. Kolosova, Khir. Pozvon., No. 1, 88–94 (2006).
A. A. Bobko, S. V. Sergeeva, E. G. Bagryanskaya, et al., Biochem. Biophys. Res. Commun., 330, No. 2, 367–370 (2005).
W. B. Ershler, J. Am. Geriatr. Soc., 41, No. 2, 176–181 (1993).
H. Geiger, G. Rennebeck, and G. Van Zant, Proc. Natl. Acad. Sci. USA, 102, No. 14, 5102–5107 (2005).
E. Henckaerts, J. C. Langer, and H. W. Snoeck, Blood, 104, No. 2, 374–379 (2004).
G. Jovcic, N. Stojanovic, M. Kataranovski, et al., Ann. Hematol., 66, No. 4, 195–201 (1993).
N. G. Kolosova, T. V. Shcheglova, S. V. Sergeeva, and L. V. Loskutova, Neurobiol. Aging, 27, No. 9, 1289–1297 (2006).
P. L. McGeer and E. G. McGeer, Ann. N. Y. Acad. Sci., 1035, 104–116 (2004).
I. A. Orlovskaya and V. A. Kozlov, Rus. J. Immunol., 6, No. 2, 168–176 (2001).
S. Sergeeva, E. Bagryanskaya, E. Korbolina, and N. Kolosova, Exp. Gerontol., 41, No. 2, 141–150 (2006).
Z. Xing, M. A. Ryan, D. Daria, et al., Blood, 108, No. 7, 2190–2197 (2006).
T. Yoshino, M. Tamura, M. Kawabe, et al., Bri. J. Haematol., 82, No. 2, 664–670 (1992).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 7, pp. 96–99, July, 2007
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Orlovskaya, I.A., Toporkova, L.B., Feofanova, N.A. et al. Peculiarities of bone marrow hemopoiesis in early aging OXYS rats. Bull Exp Biol Med 144, 86–88 (2007). https://doi.org/10.1007/s10517-007-0262-0
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DOI: https://doi.org/10.1007/s10517-007-0262-0