Skip to main content
SpringerLink
Log in

Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

PGP peptide had a protective effect in contractile dysfunction of the rat mesenteric lymph vessels under conditions of inflammation, irrespective of the time of its injection (before or after inflammatory agent). The preventive effect of this peptide is largely determined by its capacity to prevent mast cells activation. PGP injected 2 h after induction of inflammation did not inhibit secretory activity of mast cells, which suggests other mechanisms of its therapeutic action.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. N. Kopylova, E. A. Smirnova, and L. Ts. Sanzhieva, Vestn. Moskovsk. Gos. Universiteta, Series 16, Biology, No. 2, 6–9 (2006).

  2. G. N. Kopylova, E. A. Smirnova, L. Ts. Sanzhieva, et al., Byull. Eksp. Biol. Med., 136, No. 5, 497–499 (2003).

    Article  Google Scholar 

  3. B. A. Umarova, G. N. Kopylova, E. A. Smirnova, et al., Ibid., 136, No. 10, 371–373 (2003).

    Google Scholar 

  4. B. A. Umarova, T. V. Lelekova, G. N. Kopylova, et al., Ibid., 142, No. 9, 248–251 (2006).

    Google Scholar 

  5. F. B. Shapiro, B. A. Umarova, and S. M. Strukova, Vestn. Moskovsk. Gos. Universiteta, Series 16, Biology, No. 1, 27–32 (1994).

  6. J. Donelan, W. Boucher, N. Papadopoulou, et al., Proc. Natl. Acad. Sci. USA, 103, No. 20, 7759–7764 (2006).

    Article  PubMed  CAS  Google Scholar 

  7. M. F. Gurish and K. F. Austen, J. Exp. Med., 194, No. 1, F1–F5 (2001).

    Article  PubMed  CAS  Google Scholar 

  8. J. E. Mawdsley and D. S. Rampton, Gut, 54, No. 10, 1481–1491 (2005).

    Article  PubMed  CAS  Google Scholar 

  9. G. Pejler, Inflamm. Res., 48, No. 6, 344–350 (1999).

    Article  PubMed  CAS  Google Scholar 

  10. M. Schmelz and L. J. Petersen, News Physiol. Sci., 16, 33–37 (2001).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    B. A. Umarova, G. N. Kopylova, T. V. Lelekova, Z. V. Bakaeva, E. L. Goncharova & G. E. Samonina

Authors
  1. B. A. Umarova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. N. Kopylova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. V. Lelekova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Z. V. Bakaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. L. Goncharova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. E. Samonina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. A. Umarova.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 7, pp. 32–35, July, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Umarova, B.A., Kopylova, G.N., Lelekova, T.V. et al. Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation. Bull Exp Biol Med 144, 29–32 (2007). https://doi.org/10.1007/s10517-007-0245-1

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0245-1

Key Words

Search

Navigation