Abstract
The effects of P2-receptor agonists on myocardial contractility were examined in rats aging 14–100 days. ATP and its stable analog 2-methylthio-ATP potentiated the contraction force of isolated myocardial strips in a dose-dependent manner. The agonist concentrations producing the positive inotropic effect increased from days 14 to 100 of life. The efficiency of extracellular purines depends on animal age: in 14-and 56-day rats the positive inotropic effects of ATP and 2-methylthio-ATP were similar, while in 100-day rats ATP produced more pronounced effect than 2-methylthio-ATP.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. A. Anikina, F. G. Sitdikov, E. Yu. Khamzina, and G. A. Bilalova, Byull. Eksp. Biol.Med., 140, No. 11, 490–492 (2000).
V. V. Eliseev, Adenosine Control of Physiological Functions in Organism [in Russian], St. Petersburg (1991).
A. A. Ziganshin, ATP Receptor Pharmacology [in Russian], Ìoscow (1999).
D. J. Browse, R. T. Mathie, I. S. Benjamin, and B. Alexander, Comp. Hepatol., 2, No. 1, 9 (2003).
V. Ralevic and G. Burnstock, Pharmacol. Rev., 50, No. 3, 413–492 (1998).
A. Rubino, S. Amerini, F. Ledda, and L. Mantelli, Br. J. Pharmacol., 105, No. 3, 516–520 (1992).
G. Vassort, Physiol. Rev., 81, No. 2, 767–806 (2001).
H. Zimmermann, Naunyn Schmiedeberg’s Arch. Pharmacol., 362, Nos. 4–5, 299–309 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 7, pp. 7–10, July, 2007
Rights and permissions
About this article
Cite this article
Anikina, T.A., Bilalova, G.A., Zverev, A.A. et al. Effect of ATP and its analogs on contractility of rat myocardium during ontogeny. Bull Exp Biol Med 144, 4–7 (2007). https://doi.org/10.1007/s10517-007-0239-z
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0239-z