Abstract
Comparative morphometrical study of the renal glomerular system was carried out in hypertensive NISAG rats treated with hypotensive drugs during the prepubertal period. Blockade of the renin-angiotensin system with enalapril or losartan during the critical period of ontogeny (the 2nd month of life) produced a long-term hypotensive and renoprotective effect. Treatment with α-adrenoblocker terazosin during this period of ontogeny produced a less pronounced hypotensive effect, though with renoprotection. Corinfar (Ca2+ channel blocker) was least effective.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 695–699, June, 2007
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Filyushina, E.E., Shmerling, M.D., Lazarev, V.A. et al. Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats. Bull Exp Biol Med 143, 749–752 (2007). https://doi.org/10.1007/s10517-007-0232-6
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DOI: https://doi.org/10.1007/s10517-007-0232-6