Abstract
We studied the effects of daily 1-h immobilization of female rats on days 15–18 of pregnancy on functional activity of the hypothalamic-pituitary-adrenocortical system and its sensitivity to regulatory signals realized by the negative feedback mechanism in female progeny during aging. Prenatal stress potentiated the inhibitory processes in young animals. In aging female rats, the sensitivity of the hypothalamic-pituitary-adrenocortical system to feedback signals significantly decreased and circadian stress reactivity was disturbed. These data suggest that maternal stress modifies the age-related pattern of the hypothalamic-pituitary-adrenocortical regulation in female progeny.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 686–689, June, 2007
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Pivina, S.G., Akulova, V.K. & Ordyan, N.E. Changed activity of the hypothalamic-pituitary-adrenocortical system in prenatally stressed female rat during aging. Bull Exp Biol Med 143, 740–743 (2007). https://doi.org/10.1007/s10517-007-0229-1
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DOI: https://doi.org/10.1007/s10517-007-0229-1