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Effect of compound GB-115 on morphine-induced analgesia

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Abstract

Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice. This potentiation of antinociceptive activity of morphine was probably related to the interaction of GB-115 with supraspinal opioidergic mechanisms.

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References

  1. L. G. Kolik, T. A. Gudasheva, and S. B. Seredenin, Byull. Eksp. Biol. Med., 135, No. 5, 519–523 (2003).

    Article  Google Scholar 

  2. V. Dauge, F. Beslot, T. Matsui, and B. P. Roques, Neurosci. Lett., 306, Nos. 1–2, 41–44 (2001).

    Article  PubMed  CAS  Google Scholar 

  3. A. E. Friedrich and G. B. Gebhart, J. Pharmacol. Exp. Ther., 292, No. 2, 538–544 (2000).

    PubMed  CAS  Google Scholar 

  4. D. Le Bars, M. Gozariu, and S. W. Cadden, Pharmacol. Rev., 53, No. 4, 597–652 (2001).

    PubMed  Google Scholar 

  5. F. Noble, S. A. Wank, J. N. Crawley, et al., Ibid., 51, No. 4, 745–781 (1999).

    PubMed  CAS  Google Scholar 

  6. B. Pommier, F. Beslot, A. Simon, et al., J. Neurosci., 22, No. 5, 2005–2011 (2002).

    PubMed  CAS  Google Scholar 

  7. B. P. Roques and F. Noble, Neurochem. Res., 21, No. 11, 1397–1410 (1996).

    Article  PubMed  CAS  Google Scholar 

  8. L. Singh, R. J. Oles, M. J. Field, et al., Br. J. Pharmacol., 118, No. 5, 1317–1325 (1996).

    PubMed  CAS  Google Scholar 

  9. T. W. Vanderah, R. N. Bernstein, H. I. Yamamura, et al., J. Pharmacol. Exp. Ther., 278, No. 1, 212–219 (1996).

    PubMed  CAS  Google Scholar 

  10. A. Veraksits, K. Runkorg, K. Kurrikoff, et al., Psychopharmacology (Berl.), 166, No. 2, 168–175 (2003).

    CAS  Google Scholar 

  11. Z. Wiesenfeld-Hallin, G. de Arauja Luca, P. Alster, et al., Brain Res., 848, Nos. 1–2, 78–89 (1999).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to L. G. Kolik.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 645–647, June, 2007

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Kolik, L.G., Zhukov, V.N. & Seredenin, S.B. Effect of compound GB-115 on morphine-induced analgesia. Bull Exp Biol Med 143, 703–705 (2007). https://doi.org/10.1007/s10517-007-0219-3

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  • DOI: https://doi.org/10.1007/s10517-007-0219-3

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