Abstract
Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice. This potentiation of antinociceptive activity of morphine was probably related to the interaction of GB-115 with supraspinal opioidergic mechanisms.
Similar content being viewed by others
References
L. G. Kolik, T. A. Gudasheva, and S. B. Seredenin, Byull. Eksp. Biol. Med., 135, No. 5, 519–523 (2003).
V. Dauge, F. Beslot, T. Matsui, and B. P. Roques, Neurosci. Lett., 306, Nos. 1–2, 41–44 (2001).
A. E. Friedrich and G. B. Gebhart, J. Pharmacol. Exp. Ther., 292, No. 2, 538–544 (2000).
D. Le Bars, M. Gozariu, and S. W. Cadden, Pharmacol. Rev., 53, No. 4, 597–652 (2001).
F. Noble, S. A. Wank, J. N. Crawley, et al., Ibid., 51, No. 4, 745–781 (1999).
B. Pommier, F. Beslot, A. Simon, et al., J. Neurosci., 22, No. 5, 2005–2011 (2002).
B. P. Roques and F. Noble, Neurochem. Res., 21, No. 11, 1397–1410 (1996).
L. Singh, R. J. Oles, M. J. Field, et al., Br. J. Pharmacol., 118, No. 5, 1317–1325 (1996).
T. W. Vanderah, R. N. Bernstein, H. I. Yamamura, et al., J. Pharmacol. Exp. Ther., 278, No. 1, 212–219 (1996).
A. Veraksits, K. Runkorg, K. Kurrikoff, et al., Psychopharmacology (Berl.), 166, No. 2, 168–175 (2003).
Z. Wiesenfeld-Hallin, G. de Arauja Luca, P. Alster, et al., Brain Res., 848, Nos. 1–2, 78–89 (1999).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 645–647, June, 2007
Rights and permissions
About this article
Cite this article
Kolik, L.G., Zhukov, V.N. & Seredenin, S.B. Effect of compound GB-115 on morphine-induced analgesia. Bull Exp Biol Med 143, 703–705 (2007). https://doi.org/10.1007/s10517-007-0219-3
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0219-3