Acute experiments on narcotized cats with depressor shifts in the circulatory system induced by acetylcholine and histamine revealed more pronounced decrease in vascular resistance in the brachiocephalic artery in comparison with the thoracic aorta basin. Cardiac output was redistributed between these vascular basins: the bloodflow increased in the brachiocephalic artery and decreased in the thoracic aorta. Hemodynamic shifts in the arterial compartment of the vascular system are presumably essential for changes in the bloodflow in venae cavae.