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Structural and functional changes in myocardial thin filaments in experimental hypothyrosis

Bulletin of Experimental Biology and Medicine volume 143, pages 587–589 (2007)Cite this article

Abstract

Fluorescence resonance energy transfer study revealed decreased intermonomer mobility of Ca-actin and Mg-actin filaments of myocardial myofibrils in myocardial dystrophy caused by diffuse endocrine disorders, e. g. hypothyrosis. Cis374 axial distance in Ca-actin filament protomer increased in hypothyrosis. Intracellular pH has no effect on intermonomer mobility of Ca-actin filament.

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Affiliations

  1. N. V. Karsanov National Center of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi

    G. V. Sukoyan, T. M. Berberashvili & K. Dzh. Asatiani

Authors
  1. G. V. Sukoyan
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  2. T. M. Berberashvili
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  3. K. Dzh. Asatiani
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 5, pp. 522–524, May, 2007

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Sukoyan, G.V., Berberashvili, T.M. & Asatiani, K.D. Structural and functional changes in myocardial thin filaments in experimental hypothyrosis. Bull Exp Biol Med 143, 587–589 (2007). https://doi.org/10.1007/s10517-007-0187-7

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  • DOI: https://doi.org/10.1007/s10517-007-0187-7

Key Words

  • hypothyrosis
  • actin
  • myocardium
  • structural xxx conformation changes