Abstract
In human cells, expression of IL-4 gene involves alternative mRNA splicing. IL-4δ2 splice variant is an antagonist of full-length IL-4 protein and blocks its effect on the functional activity of immunocompetent cells. The effect of recombinant IL-4δ2 on cytokine-producing activity of human peripheral blood mononuclear cells is shown for the first time.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 78–80, January, 2007
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Silkov, A.N., Gavrilenko, V.A., Denisova, V.V. et al. Effects of recombinant IL-4δ2 on human peripheral blood mononuclears. Bull Exp Biol Med 143, 72–74 (2007). https://doi.org/10.1007/s10517-007-0020-3
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DOI: https://doi.org/10.1007/s10517-007-0020-3