Abstract
We studied the effect of spirochete Borrelia burgdorferi sensu lato cell membrane proteins on excitability of myelinated nerve fiber. It was found that cell surface proteins of spirochetes B. burgdorferi s. s. bind to Ranvier nodes of the axon and to Schwann cells. Binding of B. burgdorferi s. s. and B. garinii to the nerve fiber modulates the amplitude and conduction velocity of the action potential, while B. afzelii had no effect on these parameters. The decrease in the spike amplitude and conduction velocity during sorption of B. burgdorferi s. s. or cell wall proteins was accompanied by desorption of membrane-bound calcium.
Similar content being viewed by others
References
V. N. Karnaukhov, Spectral Luminescence Analysis of the Cell [in Russian], Moscow (1978).
G. V. Maksimov, T. A. Brindikova, L. A. Erokhova, et al., Biofizika, 48, No. 4, 683–689 (2003).
G. V. Maksimov and S. N. Orlov, Calcium Ion Transport in Function of the Nerve Fiber: Mechanisms and Regulation [in Russian], Moscow (1994).
I. Tasaki, Nerve Excitation [in Russian], Moscow (1971).
P. B. Backenson, J. L. Coleman, and J. L. Benach, Infect. Immun., 63, No. 8, 2811–2817 (1995).
A. G. Barbour, J. Biol. Med., 57, No. 4, 521–525 (1984).
A. B. Beklemishev, A. K. Dobrotvorsky, A. V. Piterina, et al., FEMS Microbiol. Lett., 227, No. 2, 157–161 (2003).
N. A. Brazhe, L. A. Erokhova, A. A. Churin, and G. V. Maksimov, J. Biol. Phys., 31, Nos. 3–4, 533–546 (2005).
J. Coburn, J. M. Leong, and J. K. Erban, Proc. Natl. Acad. Sci. USA, 90, No. 15, 7059–7063 (1993).
J. C. Garcia Monco, B. Fernandez Villar, R. C. Rogers, et al., Neurology, 42, No. 7, 1341–1348 (1992).
R. D. Isaacs, J. Clin. Invest., 93, No. 2, 809–819 (1994).
E. I. Korenberg, Y. V. Kovalevskii, M. L. Levin, and T. V. Shchyogoleva, Folia Parasitol. (Praha), 48, No. 1, 63–68 (2001).
T. Masuzawa, I. G. Kharitonenkov, T. Kadosaka, et al., Int. J. Med. Microbiol., 294, No. 7, 455–464 (2005).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 42–45, January, 2007
Rights and permissions
About this article
Cite this article
Rodionova, N.N., Brazhe, N.A., Brazhe, A.R. et al. Effect of proteins from the spirochete Borrelia burgdorferi sensu lato on myelinated nerve excitability. Bull Exp Biol Med 143, 36–39 (2007). https://doi.org/10.1007/s10517-007-0010-5
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0010-5