Abstract
We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca2+-ATPase, phospholamban, β1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca2+-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the β1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca2+-ATPase and β1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 32–37, January, 2007
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Kovlen, D.V., Tishakov, A.Y., Glotov, O.S. et al. Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure. Bull Exp Biol Med 143, 26–31 (2007). https://doi.org/10.1007/s10517-007-0008-z
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DOI: https://doi.org/10.1007/s10517-007-0008-z