Skip to main content
SpringerLink
Log in

Effect of classic convulsants on Cl− conductance of the GABAA receptor complex in membranes of cerebral cortex cells at the early stage of kindling

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Muscimol-stimulated Cl− conductance of synaptoneurosomes from the cerebral cortex of Wistar rats increased during the early stage of pharmacological kindling not inducing the seizure response in animals. Picrotoxin, bicuculline, and pentylenetetrazole potentiated inhibition of muscimol-dependent 36Cl− entry into synaptoneurosomes, which attested to increased sensitivity of the GABAA receptor/Cl− ionophore complex to classic convulsants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. S. Bazyan, V. V. Zhulin, M. N. Karpova, et al., Zh. Vyssh. Nervn. Deyat., 48, No. 1, 135–142 (1998).

    CAS  Google Scholar 

  2. A. S. Bazyan, V. V. Zhulin, M. N. Karpova, et al., Ibid., 48, No. 2, 304–311 (1998).

    CAS  Google Scholar 

  3. M. N. Karpova and I. G. Rebrov, Dysregulation Pathology [in Russian], Moscow (2002), pp. 596–604.

  4. G. N. Kryzhanovskii, Ibid., pp. 18–78.

  5. I. G. Rebrov, G. N. Kryzhanovskii, N. P. Belykh, et al., Byull. Eksp. Biol. Med., 118, No. 8, 160–163 (1994).

    CAS  Google Scholar 

  6. A. S. Bazyan, V. V. Zhulin, M. N. Karpova, et al., Brain Res., 888, No. 2, 212–220 (2001).

    Article  PubMed  CAS  Google Scholar 

  7. M. G. Corda, M. Orlandi, D. Lecca, et al., Pharmacol. Biochem. Behav., 40, No. 2, 329–333 (1991).

    Article  PubMed  CAS  Google Scholar 

  8. Y. Fathollahi, F. Motamedi, S. Semnanian, and M. Zardoshti, Brain Res., 758, Nos. 1–2, 92–98 (1997).

    Article  PubMed  CAS  Google Scholar 

  9. M. E. Gilbert, Ann. NY Acad. Sci., 933, 68–91 (2001).

    Article  PubMed  CAS  Google Scholar 

  10. E. B. Hollingsworth, E. T. McNeal, J. L. Burton, et al., J. Neurosci., 5, No. 8, 2240–2253 (1985).

    PubMed  CAS  Google Scholar 

  11. R. D. Schwartz, P. D. Suzdak, and S. M. Paul, Mol. Pharmacol., 30, No. 5, 419–426 (1986).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Epileptogenesis, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    I. G. Rebrov, M. N. Karpova, A. A. Andreev, M. V. Kalinina, N. Yu. Klishina & L. V. Kuznetsova

Authors
  1. I. G. Rebrov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. N. Karpova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Andreev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Kalinina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Yu. Klishina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. V. Kuznetsova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 17–19, January, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rebrov, I.G., Karpova, M.N., Andreev, A.A. et al. Effect of classic convulsants on Cl− conductance of the GABAA receptor complex in membranes of cerebral cortex cells at the early stage of kindling. Bull Exp Biol Med 143, 12–14 (2007). https://doi.org/10.1007/s10517-007-0004-3

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0004-3

Key Words

Search

Navigation