Skip to main content
SpringerLink
Log in

Comparative study of analgesic potency of ACTH4–10 fragment and its analog semax

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of ACTH4–10 fragment and its analog semax on nociception were examined on various animal models. ACTH4–10 in a dose of 0.5 mg/kg decreased nociception in rats during hindpaw compression test and in mice subjected to acetic acid writhing test. Lower doses of ACTH4–10 produced no analgesic effect. Semax (0.015–0.500 mg/kg) decreased pain sensitivity in all experimental models. Hence, the substitution of three C-terminal amino acid residues in ACTH4–10 for Pro-Gly-Pro sequence augmented the analgesic potency of the peptide after its peripheral injection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. P. Ashmarin, V. N. Nezavibat’ko, N. F. Myasoedov, et al., Zh. Vyssh. Nervn. Deyat., 47, No. Ç, 420–430 (1997).

    CAS  Google Scholar 

  2. A. I. Bogdanov, T. R. Bagaeva, N. N. Fefelova, and A. A. Filaretov, Fiziol. Zh., 81, No. 3, 61–67 (1995).

    CAS  Google Scholar 

  3. O. V. Dolotov, T. S. Seredenina, H. G. Levitskaya, et al., Dokl. Akad. Nauk, 391, No. 1, 131–134 (2003).

    Google Scholar 

  4. D. M. Ivanova, H. G. Levitskaya, L. A. Andreeva, et al., Ibid, 388, No. 3, 416–419.

  5. A. Ya. Kaplan, V. B. Koshelev, V. N. Nezavibat’ko, et al., Fiziol. Chel., 18, No. 5, 104–107 (1992).

    CAS  Google Scholar 

  6. H. G. Levitskaya, E. A. Sebentsova, L. A. Andreeva, et al., Fiziol. Zh., 88, No. 11, 1369–1377 (2002).

    CAS  Google Scholar 

  7. I. P. Ashmarin, V. N. Nezavibatko, N. G. Levitskaya, et al., Neurosci. Res. Commun., 16, 105–112 (1995).

    CAS  Google Scholar 

  8. V. Klusa, S. Germane, S. Svirskis, and J. E. Wikberg, Neuropeptides, 35, No. 1, 50–57 (2001).

    Article  PubMed  CAS  Google Scholar 

  9. A. M. Kshatri and P. A. Foster, Reg. Anesth., 22, No. 5, 432–434 (1997).

    Article  PubMed  CAS  Google Scholar 

  10. X. C. Li, H. D. Li, and B. Y. Zhao, Zhongguo Yao Li Xue Bao, 11, No. 1, 89–92 (1990).

    PubMed  CAS  Google Scholar 

  11. V. N. Potaman, L. Y. Alfeeva, A. A. Kamensky, et al., Biochem. Biophys. Res. Commun., 176, No. 2, 741–746 (1991).

    Article  PubMed  CAS  Google Scholar 

  12. K. Starowicz and B. Przewlocka, Life Sci., 73, No. 7, 823–847 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. C. Takeshige, M. Tsuchiya, W. Zhao, and S. Guo, Brain. Res. Bull., 26, No. 5, 779–788 (1991).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    D. M. Ivanova & A. A. Kamenskii

  2. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow

    N. G. Levitskaya, L. A. Andreeva & N. F. Myasoedov

Authors
  1. D. M. Ivanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. G. Levitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. A. Andreeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Kamenskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. F. Myasoedov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. G. Levitskaya.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 8–12, January, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivanova, D.M., Levitskaya, N.G., Andreeva, L.A. et al. Comparative study of analgesic potency of ACTH4–10 fragment and its analog semax. Bull Exp Biol Med 143, 5–8 (2007). https://doi.org/10.1007/s10517-007-0002-5

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0002-5

Key Words

Search

Navigation