Abstract
The behavior of CBA mice in the hole-board test and elevated plus maze was studied after intraperitoneal injection of skatole leading to destruction of the epithelium in the main olfactory system. Locomotor and exploratory activity and degree of anxieties were low in intact mice. Anosmia was accompanied by an increase in orientation and exploratory activities and degree of anxiety.
Similar content being viewed by others
References
A. S. Bazyan, Neirokhimiya, 16, No. 2, 88–103 (1999).
R. G. Kozhedub, T. A. Korol’kova, S. N. Kozhechkin, et al., Dokl. Akad. Nauk, 372, No. 3, 1–4 (2000).
N. E. Makarchuk and A. V. Kaluev, Olfaction and Behavior [in Russian], Kiev (2000).
H. T. Jansen, G. A. Iwamoto, and G. L. Jacson, Brain Res. Bull., 45, No. 1, 27–39 (1998).
S. A. Mc Bride and B. Slotnick, Behav. Neurosci., 111, No. 6, 1273–1284 (1997).
M. A. Miller and M. A. O’Bryan, Ultrastruct. Pathol., 27, No. 1, 13–21 (2003).
D. B. Peele, S. D. Allison, B. Bolon, et al., Toxicol. Appl. Pharmacol., 107, No. 2, 191–202 (1991).
E. A. Stone, S. J. Manavalan, Yi Zhang, and D. Quartermain, Neuropsychopharmacology, 12, No. 1, 65–71 (1995).
M. A. Turk, R. G. Breeze, and A. M. Gallina, Am. J. Pathol., 110, No. 2, 209–218 (1987).
Author information
Authors and Affiliations
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 4–7, January, 2007
Rights and permissions
About this article
Cite this article
Kudyakova, T.I., Sarycheva, N.Y. & Kamenskii, A.A. Orientation and exploratory behavior and anxiety of CBA mice with anosmia induced by N-trimethylindole (skatole). Bull Exp Biol Med 143, 1–4 (2007). https://doi.org/10.1007/s10517-007-0001-6
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-007-0001-6