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Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 6, pp 707–709 | Cite as

Effectiveness of combined treatment with superoxide dismutase and reamberin during skin ischemia

  • V. P. Galenko-Yaroshevskii
  • A. V. Agadzhanova
  • N. V. Lapina
  • T. V. Gaivoronskaya
  • L. V. Popkova
  • I. V. Churilova
  • A. S. Gorelashvili
  • T. M. Berberashvili
  • N. A. Antelava
  • G. V. Sukoyan
Article

Abstract

Experimental skin ischemia in rats was induced by suturing a skin fold on the back with a silk thread. Combined pretreatment with superoxide dismutase (intraperitoneally) and Reamberin (intravenously) in doses of 0.01 and 6.25 mg/kg (by succinate concentration), respectively, produced a strong protective effect on the skin. The index of cytolysis decreased by 39%. The more pronounced antinecrotic effect of combined treatment with superoxide dismutase and Reamberin compared to the effect of Reamberin alone was related to a sharp increase in the reserve capacity of the antioxidant system. After combined therapy, activity of antioxidant defense enzymes not only increased, but even exceeded the normal level. The increase in activity of endogenous superoxide dismutase under the influence of combined therapy was accompanied by suppression of superoxide anion production.

Key Words

superoxide dismutase Reamberin skin ischemia antinecrotic effect 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. P. Galenko-Yaroshevskii
    • 1
    • 2
  • A. V. Agadzhanova
    • 1
    • 2
  • N. V. Lapina
    • 1
    • 2
  • T. V. Gaivoronskaya
    • 1
    • 2
  • L. V. Popkova
    • 1
    • 2
  • I. V. Churilova
    • 1
    • 2
  • A. S. Gorelashvili
    • 3
  • T. M. Berberashvili
    • 3
  • N. A. Antelava
    • 3
  • G. V. Sukoyan
    • 3
  1. 1.Kuban State Medical UniversityRussia
  2. 2.Krasnodar BranchSouthern Bureau of the Russian Academy of Medical SciencesRussia
  3. 3.N. V. Karsanov Republican Research Center for Medical Biophysics and Implementation of New Biomedical TechnologiesTbilisi

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