Abstract
Six models of experimental immunogenic uveitis induced by injection of normal horse serum were tried in rabbits. A convenient working variant of the model was developed characterized by high activity and long duration of the inflammatory process in the eye. Creation of this model requires pre-sensitization (subcutaneous injection of 5 ml normal horse serum) followed by intravitreal injection of the resolving dose of horse serum on day 9. An adapted improved model of experimental immunogenic uveitis in rabbits is proposed.
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References
A. I. Shchipanova and D. Yu. Maichuk, Immunologiya, No. 2, 45–47 (1998).
H. A. Baldwin and A. R. Borgman, Proc. Soc. Exp. Biol. Med., 133, 1326–1330 (1970).
B. Foss, Experimental Anaphylactic Iridocyclitis (1949), P. 65.
H. D. Grand, B. Schimmelpfenning, and R. Witmer, Ophthal. Res., 5, 204–214 (1973).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 598–600, November, 2006
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Neroev, V.V., Davydova, G.A. & Perova, T.S. Model of immunogenic uveitis in rabbits. Bull Exp Biol Med 142, 649–650 (2006). https://doi.org/10.1007/s10517-006-0440-5
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DOI: https://doi.org/10.1007/s10517-006-0440-5