Skip to main content
SpringerLink
Log in

Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. V. Kulikov, V. A. Kulikov, and D. V. Bazovkina, Zh. Vyssh. Nerv. Deyat., 55, No. 1, 116–122 (2005).

    Google Scholar 

  2. N. K. Popova and A. V. Kulikov, Progress in Functional Neurochemistry [in Russian], Eds. C. A. Dambinova, V. A. Arutyunyan, St. Petersburg (2003).

  3. S. H. Alves, G. Pinheiro, V. Motta, et al., Behav. Pharmacol., 15, No. 1, 37–43 (2004).

    Article  PubMed  CAS  Google Scholar 

  4. T. G. Amstislavskaya and N. K. Popova, Neurosci. Behav. Physiol., 34, No. 8, 833–837 (2004).

    Article  PubMed  CAS  Google Scholar 

  5. J. F. Cryan and I. Lucki, J. Pharmacol. Exp. Ther., 295, No. 3, 1120–1126 (2000).

    PubMed  CAS  Google Scholar 

  6. A. P. de Mello Cruz, G. Pinheiro, S. H. Alves, et al., Psychopharmacology, 182, No. 3, 345–354 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. G. Griebel, Pharmacol. Ther., 65, 319–395 (1995).

    Article  PubMed  CAS  Google Scholar 

  8. S. K. Hemrick-Luecke and R. W. Fuller, Eur. J. Pharmacol., 311, Nos. 2–3, 207–211 (1996).

    Article  PubMed  CAS  Google Scholar 

  9. F. Jenck, M. Bos, J. Wichmann, et al., Expert. Opin. Investig. Drugs., 10, 1587–1599 (1998).

    Article  Google Scholar 

  10. D. Julius, K. N. Huang, T. J. Livelli, et al., Proc. Natl. Acad. Sci. USA, 87, No. 3, 928–932 (1990).

    Article  PubMed  CAS  Google Scholar 

  11. J. I. Koenig, G. A. Gudelsky, and H. Y. Meltzer, Eur. J. Pharmacol., 137, No. 1, 1–8 (1987).

    Article  PubMed  CAS  Google Scholar 

  12. D. Kshama, H. J. Hrishikeshavan, R. Shanbhogue, and U. S. Munonyedi, Behav. Neural. Biol., 54, No. 3, 234–253 (1990).

    Article  PubMed  CAS  Google Scholar 

  13. J. F. Nash Jr., H. Y. Meltzer, and G. A. Gudelsky, Pharmacol. Biochem. Behav., 33, No. 4, 781–785 (1989).

    Article  PubMed  CAS  Google Scholar 

  14. B. A. Nic Dhonnchadha, M. Bourin, and M. Hascoet, Behav. Brain Res., 140, No. 1–2, 203–214 (2003).

    Article  PubMed  CAS  Google Scholar 

  15. M. Pompeano, J. M. Palacios, and G. Mengod, Mol. Brain Res., 23, 163–178 (1994).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    T. G. Amstislavskaya, V. V. Bulygina, M. A. Tibeikina & N. K. Popova

  2. Novosibirsk State University, Moscow

    E. G. Kuznetsova

Authors
  1. E. G. Kuznetsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. G. Amstislavskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Bulygina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. A. Tibeikina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. K. Popova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. G. Kuznetsova.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 541–544, November, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuznetsova, E.G., Amstislavskaya, T.G., Bulygina, V.V. et al. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med 142, 594–597 (2006). https://doi.org/10.1007/s10517-006-0427-2

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0427-2

Key Words

Search

Navigation