Skip to main content
SpringerLink
Log in

Effect of serum from cardiovascular patients on catalytic activity of secretory phospholipase A2 (IIA)

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Incubation of patients’ serum catalytically active by type IIA secretory phospholipase A2 (SP-IIA) with serum containing the enzyme in a high concentration but exhibiting no catalytic activity in 1:1 volume ratio led to a significant inhibition of SP-IIA catalytic activity. Donor and patient sera with low levels of SP-IIA had no effect on the serum with SP-IIA activity under these conditions. However, the increase in the content of patients’ serum with a low level of SP-IIA in the incubation mixture to 1:2 (v/v) and of donor serum to 1:3 (v/v) also led to blockade of SP-IIA catalytic activity. These results indicate that human serum contains an SP-IIA inhibitor and its concentration decreases significantly in sera with SP-IIA activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. A. Korotaeva, E. V. Samoilova, A. I. Kaminny, et al., Mol. Cell. Biochem., 270, Nos. 1–2, 107–113 (2005).

    Article  PubMed  CAS  Google Scholar 

  2. K. Kugiyama, Y. Ota, S. Sugiyama, et al., Am. J. Cardiol., 86, No. 7, 718–722 (2000).

    Article  PubMed  CAS  Google Scholar 

  3. K. Kugiyama, Y. Ota, K. Takazoe, et al., Circulation, 100, No. 12, 1280–1284 (1999).

    PubMed  CAS  Google Scholar 

  4. T. J. Nevalainen, M. M. Haapamaki, and J. M. Gronroos, Biochim. Biophys. Acta, 1488, Nos. 1–2, 83–90 (2000).

    PubMed  CAS  Google Scholar 

  5. H. W. Niessen, P. A. Krijnen, C. A. Visser, et al., Cardiovasc. Res., 60, No. 1, 68–77 (2003).

    Article  PubMed  CAS  Google Scholar 

  6. H. R. Schadlich, M. Buchler, and H. G. Beger, J. Clin. Chem. Clin. Biochem., 25, No. 8, 505–509 (1987).

    PubMed  CAS  Google Scholar 

  7. D. A. Six and E. A. Dennis, Biochim. Biophys. Acta, 1488, Nos. 1–2, 1–19 (2000).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Russian Cardiological Center, Russian Ministry of Health, Moscow

    E. V. Samoilova, A. A. Pirkova, N. V. Prokazova & A. A. Korotaeva

Authors
  1. E. V. Samoilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Pirkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. V. Prokazova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Korotaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Samoilova.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 525–527, November, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Samoilova, E.V., Pirkova, A.A., Prokazova, N.V. et al. Effect of serum from cardiovascular patients on catalytic activity of secretory phospholipase A2 (IIA). Bull Exp Biol Med 142, 581–582 (2006). https://doi.org/10.1007/s10517-006-0423-6

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0423-6

Key Words

Search

Navigation