Skip to main content
SpringerLink
Log in

Mechanisms of hemolytic anemia during experimental methemoglobinemias

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A complex study of the peripheral erythron component was performed during methemoglobinemias induced by single administration of sodium nitrate and phenylhydrazine in LD50. Administration of methemoglobin-forming agents to rats induced the development of hemolytic anemia. The pathogenesis of this disorder included significant long-term modifications of the erythrocyte membrane. The severity and duration of anemia syndrome depended on chemical structure of xenobiotics, blood methemoglobin level, and the duration of the acute period of methemoglobinemia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Biological Membranes. Methods [in Russian], Eds. J. B. Findley and U. G. Evans, Moscow (1990).

  2. Yu. A. Vladimirov and G. E. Dobretsov, Fluorescent Probes in Study of Biological Membranes [in Russian], Moscow (1980).

  3. S. V. German, Klin. Med., No. 4, 9–12 (1999).

  4. A. M. Kazennov, M. N. Maslova, and A. D. Shalabodov, Biokhimiya, No. 7, 1089–1094 (1984).

  5. I. V. Markova, V. V. Afanas’ev, and E. K. Tsybul’kin, Clinical Toxicology of Children and Adolescents [in Russian], St. Petersburg (1999), Vol. 2, pp. 234–237.

    Google Scholar 

  6. V. V. Novitskii, N. V. Ryazantseva, and E. A. Stepovaya, Physiology and Pathophysiology of Erythrocyte [in Russian], Tomsk (2004).

  7. V. V. Novitskii, I. A. Shperling, O. A. Zhatkin, et al., Toksikol. Vestn., No. 1, 7–12 (2004).

  8. Z. S. Toktamysova and N. Kh. Birzhanova, Biofizika, 35, No. 6, 1019–1020 (1990).

    PubMed  CAS  Google Scholar 

  9. F. Ligi, C. Ciacci, and F. Palma, Comp. Biochem. Physiol., 121, No. 3, 265–273 (1998).

    Article  CAS  Google Scholar 

  10. M. D. Shetlar and H. A. Hill, Environ. Health Perspect., 64, 265–281 (1985).

    PubMed  CAS  Google Scholar 

  11. G. S. Travlos, J. Mahler, H. A. Ragan, et al., Fudam. Appl. Toxicol., 30, 75–92 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Federal Agency of Public Health and Social Development, Siberian State Medical University, Tomsk

    V. V. Novitskii, N. V. Ryazantseva, I. A. Shperling, O. N. Filippova & O. A. Rogov

Authors
  1. V. V. Novitskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. V. Ryazantseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. A. Shperling
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. N. Filippova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. A. Rogov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 509–513, November, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Novitskii, V.V., Ryazantseva, N.V., Shperling, I.A. et al. Mechanisms of hemolytic anemia during experimental methemoglobinemias. Bull Exp Biol Med 142, 565–569 (2006). https://doi.org/10.1007/s10517-006-0419-2

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0419-2

Key Words

Search

Navigation