Abstract
We studied the possibility of induction of anti-GABA autoantibodies during chronic epileptization of the brain and the effect of systemic intraperitoneal administration of anti-GABA antibodies to C57Bl/6 mice on acute generalized and chronic epileptiform activity. It was found for the first time that chronic epileptization is accompanied by induction of anti-GABA autoantibody synthesis. Antibodies against GABA produced a proepileptic effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. A. Evseev, L. A. Vetrile, and M. N. Karpova, Vestn. Ros. Akad. Med. Nauk, No. 8, 43–46 (2004).
V. A. Evseev, L. A. Vetrile, and M. N. Karpova, Neiroimmunologiya, 2, No. 1, 9–11 (2004).
V. A. Evseev, T. V. Davydova, O. I. Mikovskaya, et al., Dysregulation Pathology [in Russian], Ed. G. N. Kryzhanovskii, Moscow (2002), pp. 420–428.
V. A. Evseev, M. N. Karpova, L. A. Vetrile, et al., Byull. Eksp. Biol. Med., 140, No. 9, 276–278 (2005).
S. I. Igon’kina, M. L. Kukushkin, L. A. Basharova, et al., Ibid., 131, No. 5, 517–519 (2001).
S. I. Igon’kina, M. L. Kukushkin, L. A. Vetrile, and V. A. Evseev, Patogenez, No. 1, 13–14 (2005).
M. N. Karpova, L. A. Vetrile, N. Yu. Klishina, et al., Byull. Eksp. Biol. Med., 136, No. 9, 287–289 (2003).
M. N. Karpova and I. G. Rebrov, Dysregulation Pathology [in Russian], Ed. G. N. Kryzhanovskii, Moscow (2002), pp. 596–603.
K. S. Raevskii, Patofiziologiya, No. 1, 3–9 (1990).
Y. Ganor, H. Goldberg-Stern, D. Amromd, et al., Clin. Dev. Immunol., 11, No. 3–4, 241–252 (2004).
Y. Ganor, H. Goldberg-Stern, T. Lerman-Sagie, et al., Epilepsy Res., 65, Nos. 1–2. 11–22 (2005).
P. Seguela, M. Geffard, R. Buijs, et al., Proc. Natl. Acad. Sci. USA, 81, No. 12, 3888–3892 (1984).
Y. Takahashi, H. Mori, M. Mishina, et al., Neurology, 61, No. 7, 891–896 (2003).
K. Tanaka, Adv. Neurol. Sci., 44, 13–22 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 505–508, November, 2006
Rights and permissions
About this article
Cite this article
Karpova, M.N., Vetrile, L.A., Trekova, N.A. et al. Neuroimmunomodulatory effect of antibodies against GABA on acute generalized and chronic epileptiform activity. Bull Exp Biol Med 142, 562–564 (2006). https://doi.org/10.1007/s10517-006-0418-3
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0418-3