Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 4, pp 458–460 | Cite as

Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet

  • A. A. SpasovEmail author
  • I. N. Iezhitsa
  • M. S. Kravchenko
  • V. B. Pisarev
  • G. L. Snigur
Article

Abstract

Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not increase its level. L-Carnitine, but not racemate and D-stereoisomer, promoted recovery of the skeletal muscle fiber thickness and exercise performance of rats.

Key Words

L-, D-, and DL-carnitine stereopharmacology carnitine deficiency exercise performance skeletal muscles 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. Czeczot and D. Scibior, Postepy Hig. Med. Dosw. (Online), 59, 9–19 (2005).Google Scholar
  2. 2.
    M. L. Dubelaar, C. M. Lucas, and W. C. Hulsmann, Am. J. Physiol., 260, No. 2, Pt. 1, E189–E193 (1991).PubMedGoogle Scholar
  3. 3.
    J. M. Duran, M. J. Peral, M. L. Calonge, and A. A. Ilundain, J. Membr. Biol., 185, No. 1, 65–74 (2002).PubMedCrossRefGoogle Scholar
  4. 4.
    A. M. Evans and G. Fornasini, Clin. Pharmacokinet., 42, No. 11, 941–967 (2003).PubMedCrossRefGoogle Scholar
  5. 5.
    E. F. Gilbert, Pathology, 17, No. 2, 161–171 (1985).PubMedGoogle Scholar
  6. 6.
    C. J. Gross and L. M. Henderson, Biochim. Biophys. Acta, 772, No. 2, 209–219 (1984).PubMedCrossRefGoogle Scholar
  7. 7.
    R. Mehvar, D. R. Brocks, and M. Vakily, Clin. Pharmacokinet., 41, No. 8, 533–558 (2002).PubMedCrossRefGoogle Scholar
  8. 8.
    P. Molstad, Biochim. Biophys. Acta, 597, No. 1, 166–173 (1980).PubMedCrossRefGoogle Scholar
  9. 9.
    Monoghraph. L-Carnitine, Altern. Med. Rev., 10, No. 1, 42–50 (2005).Google Scholar
  10. 10.
    D. J. Paulson and A. L. Shug, Life Sci., 28, No. 26, 2931–2938 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    C. J. Rebouche, J. Nutr., 113, No. 10, 1906–1913 (1983).PubMedGoogle Scholar
  12. 12.
    M. Spaniol, H. Brooks, L. Auer, et al., Eur. J. Biochem., 268, 1876–1887 (2001).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • A. A. Spasov
    • 1
    Email author
  • I. N. Iezhitsa
    • 1
  • M. S. Kravchenko
    • 1
  • V. B. Pisarev
    • 1
  • G. L. Snigur
    • 1
  1. 1.Institute of PharmacologyVolgograd State Medical UniversityRussia

Personalised recommendations