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Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors

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Abstract

Intravenous injection of cannabinoids dissolved in cremophore EL:ethanol:NaCl mixture and water-soluble emulsion of the same cannabinoids caused identical negative chronotropic effects in chloralose-narcotized rats. Selective CB1 and CB2 receptor antagonist HU-210 also induced a negative chronotropic effect in rats, while pre-injection of CB1 receptor antagonist SR 141716A completely abolished this effect of HU-210. Selective CB2 receptor antagonist SR 144528 had no effect on HU-210-induced bradycardia. Preinjection of ganglioblocker hexamethonium also did not abolish the negative chronotropic effect of HU-210 and ACPA. Perfusion of isolated rat heart with Krebs-Henseleit solution containing HU-210 in a final concentration of 100 nM reduced heart rate. It was shown that the negative chronotropic effect of cannabinoids is mediated through activation of cardiac CB1 receptors.

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References

  1. A. V. Krylatov, N. A. Bernatskaya, L. N. Maslov, et al. Ros. Fiziol. Zh., 88, No. 5, 560–567 (2002).

    CAS  Google Scholar 

  2. L. N. Maslov, O. V. Lasukova, A. V. Krylatov, et al., Ibid., 89, No. 9, 1108–1116 (2003).

    CAS  Google Scholar 

  3. A. Bonz, M. Laser, S. Kullmer, et al., J. Cardiovasc. Pharmacol., 41, No. 4, 657–664 (2003).

    Article  PubMed  CAS  Google Scholar 

  4. C. C. Felder, J. S. Veluz, H. L. Williams, et al., Mol. Pharmacol., 42, No. 5, 838–845 (1992).

    PubMed  CAS  Google Scholar 

  5. A. C. Howlett, F. Barth, T. I. Bonner, et al. Pharmacol. Rev., 54, 161–202 (2002).

    Article  PubMed  CAS  Google Scholar 

  6. R. G. Pertwee, Curr. Med. Chem., 6, No. 8, 635–664 (1999).

    PubMed  CAS  Google Scholar 

  7. M. D. Randall, D. Harris, D. A. Kendall, and V. Ralevic, Pharmacol. Ther., 95, No. 2, 191–202 (2002).

    Article  PubMed  CAS  Google Scholar 

  8. G. E. Sander, R. F. Lowe, M. B. Given, and T. D. Giles, Am. J. Cardiol., 64, No. 6, 44C–50C (1989).

    Article  PubMed  CAS  Google Scholar 

  9. H. Vidrio, M. A. Sanchez-Salvatori, and M. Medina, J. Cardiovasc. Pharmacol., 28, No. 2, 332–336 (1996).

    Article  PubMed  CAS  Google Scholar 

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Correspondence to L. N. Maslov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 433–436, October, 2006

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Krylatov, A.V., Maslov, L.N., Ermakov, S.Y. et al. Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors. Bull Exp Biol Med 142, 450–453 (2006). https://doi.org/10.1007/s10517-006-0389-4

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  • DOI: https://doi.org/10.1007/s10517-006-0389-4

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