Abstract
N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson’s disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 406–408, October, 2006
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Bobrov, M.Y., Lyzhin, A.A., Andrianova, E.L. et al. Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine. Bull Exp Biol Med 142, 425–427 (2006). https://doi.org/10.1007/s10517-006-0383-x
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DOI: https://doi.org/10.1007/s10517-006-0383-x
Key Words
- N-docosahexaenoyl dopamine
- N-acyldopamines
- antioxidants
- neuroprotection
- Parkinson’s disease