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Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging

Bulletin of Experimental Biology and Medicine volume 142, pages 356–359 (2006)Cite this article

Abstract

A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.

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Authors and Affiliations

  1. Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev

    O. V. Korkushko, V. B. Shatilo & I. A. Antonyuk-Shcheglova

  2. St. Petersburg Institute of Bioregulation and Gerontology, North Western Division of Russian Academy of Medical Sciences, Russia

    V. Kh. Khavinson

Authors
  1. O. V. Korkushko
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  2. V. Kh. Khavinson
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  3. V. B. Shatilo
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  4. I. A. Antonyuk-Shcheglova
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Corresponding author

Correspondence to V. Kh. Khavinson.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 9, pp. 328–332, September, 2006

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Korkushko, O.V., Khavinson, V.K., Shatilo, V.B. et al. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med 142, 356–359 (2006). https://doi.org/10.1007/s10517-006-0365-z

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  • DOI: https://doi.org/10.1007/s10517-006-0365-z

Key Words

  • pineal gland peptides
  • epithalamine
  • accelerated aging
  • prevention