Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 2, pp 202–204 | Cite as

Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis

  • A. A. Uyanaev
  • V. P. Fisenko
Pharmacology and Toxicology


Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals. Afobazol was low effective in preventing manifestations of learned helplessness, but if used for a long time, it reduced the incidence of learned helplessness development by increasing the percent of untrained animals.

Key Words

noopept afobazol neurosis learned helplessness 


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  1. 1.
    T. A. Voronina, Pharmacology of Nootropes (Experimental and Clinical Study) [in Russian], Moscow (1989).Google Scholar
  2. 2.
    T. A. Voronina and S. B. Seredenin, Eksp. Klin. Farmakol., 61, No. 4, 3–10 (1998).PubMedGoogle Scholar
  3. 3.
    G. M. Molodavkin, G. G. Borlikova, et al., Ibid., 63, No. 2, 9–11 (2000).PubMedGoogle Scholar
  4. 4.
    A. B. Saltykov, A. V. Toloknov, and N. K. Khitrov, Behavior and Indefinite Environment [in Russian], Moscow (1996).Google Scholar
  5. 5.
    A. B. Saltykov, A. V. Toloknov, and N. K. Khitrov, Pat. Fiziol., Nos. 5–6, 5–7 (1997).Google Scholar
  6. 6.
    S. B. Seredenin, T. A. Voronina, R. U. Ostrovskaya, et al., Manual of Experimental (Preclinical) Studies of New Drugs [in Russian], Moscow (2000), pp. 126–159.Google Scholar
  7. 7.
    A. A. Uyanaev, V. P. Fisenko, and N. K. Khitrov, Byull. Eksp. Biol. Med., 136, No. 8, 187–189 (2003).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • A. A. Uyanaev
    • 1
  • V. P. Fisenko
    • 1
  1. 1.Department of Pharmacology, Therapeutic FacultyI. M. Setchenov Moscow Medical AcademyRussia

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