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Effect of various E. coli LPS chemotypes on apoptosis and activation of human neutrophils

Bulletin of Experimental Biology and Medicine volume 142, pages 173–175 (2006)Cite this article

Abstract

We studied the effects of various Escherichia coli LPS chemotypes on the production of reactive oxygen species and regulation of apoptosis in human neutrophils. A correlation was found between the increase in chemiluminescence (Re-LPS<Ra-LPS<S-LPS) and lengthening of the polysaccharide chain in endotoxins. Shortening of the polysaccharide chain was associated with more pronounced inhibition of neutrophil apoptosis under the influence of endotoxins, which correlated with the increase in hydrophobicity of these chemotypes.

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Affiliations

  1. I. M. Sechenov Moscow Medical Academy, Russia

    M. G. Vinokurov, M. M. Yurinskaya, I. R. Prokhorenko & S. V. Grachev

  2. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino

    M. G. Vinokurov & M. M. Yurinskaya

  3. Institute of Fundamental Problems of Biology, Russian Academy of Sciences, Pushchino

    I. R. Prokhorenko & S. V. Grachev

Authors
  1. M. G. Vinokurov
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  2. M. M. Yurinskaya
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  3. I. R. Prokhorenko
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  4. S. V. Grachev
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Correspondence to M. G. Vinokurov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 136–138, August, 2006

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Vinokurov, M.G., Yurinskaya, M.M., Prokhorenko, I.R. et al. Effect of various E. coli LPS chemotypes on apoptosis and activation of human neutrophils. Bull Exp Biol Med 142, 173–175 (2006). https://doi.org/10.1007/s10517-006-0319-5

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  • DOI: https://doi.org/10.1007/s10517-006-0319-5

Key Words

  • endotoxin chemotypes
  • neutrophils
  • apoptosis
  • reactive oxygen species