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Role of NO in the systemic hemodynamic response to β2-adrenoceptor stimulation

Bulletin of Experimental Biology and Medicine volume 142, pages 165–168 (2006)Cite this article

Abstract

Blockade of NO synthesis in most narcotized rats was followed by an increase in depressor effects (by 45%) and decrease in total peripheral resistance (by 63%) upon treatment with isopropyl norepinephrine (isoproterenol). Our results indicate that NO secretion in the endothelium modulates the systemic hemodynamic response to β2-adrenoceptor stimulation.

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Affiliations

  1. Laboratory for Physiology of Blood Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    L. I. Osadchii, T. V. Balueva & I. V. Sergeev

Authors
  1. L. I. Osadchii
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  2. T. V. Balueva
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  3. I. V. Sergeev
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 128–131, August, 2006

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Osadchii, L.I., Balueva, T.V. & Sergeev, I.V. Role of NO in the systemic hemodynamic response to β2-adrenoceptor stimulation. Bull Exp Biol Med 142, 165–168 (2006). https://doi.org/10.1007/s10517-006-0317-7

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  • DOI: https://doi.org/10.1007/s10517-006-0317-7

Key Words

  • blood pressure
  • total peripheral resistance
  • isopropyl norepinephrine (isoproterenol)
  • NO synthesis blockade