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Role of NO in the systemic hemodynamic response to β2-adrenoceptor stimulation

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Abstract

Blockade of NO synthesis in most narcotized rats was followed by an increase in depressor effects (by 45%) and decrease in total peripheral resistance (by 63%) upon treatment with isopropyl norepinephrine (isoproterenol). Our results indicate that NO secretion in the endothelium modulates the systemic hemodynamic response to β2-adrenoceptor stimulation.

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Authors and Affiliations

  1. Laboratory for Physiology of Blood Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    L. I. Osadchii, T. V. Balueva & I. V. Sergeev

Authors
  1. L. I. Osadchii
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  2. T. V. Balueva
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  3. I. V. Sergeev
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 128–131, August, 2006

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Osadchii, L.I., Balueva, T.V. & Sergeev, I.V. Role of NO in the systemic hemodynamic response to β2-adrenoceptor stimulation. Bull Exp Biol Med 142, 165–168 (2006). https://doi.org/10.1007/s10517-006-0317-7

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  • DOI: https://doi.org/10.1007/s10517-006-0317-7

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