Abstract
The development of autoimmune disease in Fas-deficient MRLMpJ/lpr mice is associated with a relative decrease in the content of bone marrow CD34+ cells, which can attest to intensification of migration of early hemopoietic precursors from the bone marrow. The intensity of CD34+ apoptosis is high in young healthy MRLMpJ/lpr mice in comparison with the control, but decreases during the development of autoimmune disease. Proliferative activity of CD34+ cell population surpassed the control in all mouse groups, except AID2. The detected shifts in quantitative and qualitative parameters of CD34+ cells attest to an important role of stem hemopoietic precursors in the formation of autoimmune disease in MRLMpJ/lpr mice.
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Translated from Kletochnye Tekhnologii v Biologii i Medicine, No. 3, pp. 154–156, August, 2006
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Feofanova, N.A., Toporkova, L.B., Tikhonova, M.A. et al. Cell cycle of bone marrow CD34+ cells during autoimmune disease development in MRLMpJ/lpr mice. Bull Exp Biol Med 142, 137–139 (2006). https://doi.org/10.1007/s10517-006-0312-z
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DOI: https://doi.org/10.1007/s10517-006-0312-z