Abstract
Cultured pure population of Ito cells isolated from adult rat liver expressed epithelial markers cytokeratin-8, α-fetoprotein, and γ-glutamyl transpeptidase after forming a dense monolayer. Mesenchymal-epithelial transformation of these cells is possible, which suggests them as candidates of hepatic stem cells.
Similar content being viewed by others
References
A. P. Kiyasov, Tsitologiya, 40, No. 10, 876–882 (1998).
I. V. Uryvaeva, E. B. Tsitrin, S. I. Gorodetskii, et al., Dokl. Rossisk. Akad. Nauk, 398, No. 3, 422–425 (2004).
M. R. Alison, P. Vig, F. Russo, et al., Cell Prolif., 37, 1–21 (2004).
G. Alpini, J. O. Phillips, B. Vroman, et al., Hepatol., 20, 494–514 (1994).
S. Baba, H. Fujii, T. Hirose, et al., J. Hepatol., 40, No. 2, 331–334 (2004).
J. Chagraoui, A. Lepage-Noll, A. Anjo, et al., Blood, 101, 2973–2982 (2003).
A. Geerts, J. Hepatol., 40, 331–334 (2004).
A. P. Kiassov, P. Van Eyken, J. F. van Pely, et al., Differentiation, 59, 253–258 (1995).
D. L. Knook, A. M. Sefelaar, and A. M. Leeuw, Exp. Cell Res., 139, 468–471 (1982).
K. D. Lee, T. K. Kuo, J. Whang-Peng, et al., Hepatology, 40, No. 6, 1256–1259 (2004).
Y. S. Lim and H. S. Lee, Taechan. Kan. Hakhoe. Chi., 8, No. 1, 90–99 (2002).
Y. S. Lim, K. A. Kim, J. O. Jung, et al., Histochem. Cell Biol., 118, No. 2, 127–136 (2004).
A. Mabuchi, I. Mullaney, P. W. Sheard, et al., 40, No. 6, 910–916 (2004).
S. Paku, J. Schnur, P. Nagy, et al., Am. J. Pathol., 158, No. 4, 1313–1323 (2001).
A. M. Rutenberg, H. Kim, W. Fischbein, et al. J. Histochem. Cytochem., 17, 517–526 (1969).
S. Sell and H. A. Dunsford, Am. J. Pathol., 134, 1347–1363 (1989).
M. J. Seo, S. Y. Suh, Y. C. Bae, et al., Biochem. Biophys. Res. Commun., 328, No. 1, 258–264 (2005).
D. L. Suskind and M. O. Muench, J. Hepatol., 40, No. 2, 331–334 (2004).
S. S. Thorgeirsson and J. W. Grisham, Hepatology, 43, No. 1, 2–8 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Kletochnye Tekhnologii v Biologii i Medicine, No. 3, pp. 150–153, August, 2006
Rights and permissions
About this article
Cite this article
Kiyasov, A.P., Gumerova, A.A. & Titova, M.A. Mesenchymal-epithelial transformation of Ito cells in vitro . Bull Exp Biol Med 142, 133–136 (2006). https://doi.org/10.1007/s10517-006-0311-0
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-006-0311-0